Table 3.

Association estimates of the maternal risk factors and CAP network components.

Maternal covariates	CAP C2		CAP C4		CAP C5		CAP C6
	β (95% CI)	p -value	β (95% CI)	p -value	β (95% CI)	p -value	β (95% CI)	p -value
Maternal psychological factors	0.3 (−0.06; 0.66)	0.3	0.13 (−0.2; 0.46)	1	−0.39 (−0.66; −0.12)	0.018	−0.46 (−0.73; −0.2)	0.0027
Maternal polysubstance use	0.29 (−0.38; 0.95)	1	−0.34 (−0.91; 0.23)	0.66	0.13 (−0.13; 0.34)	0.93	0.21 (−0.11; 0.54)	0.54
Maternal smoking	−0.21 (−0.91; 0.48)	1	0.25 (−0.36; 0.85)	1	0.06 (−0.23; 0.34)	1	−0.02 (−0.37; 0.33)	1

Association estimates of the maternal risk factors and the CAP network components that were significantly different between infants with prenatal opioid exposure and control infants. For each network, Bonferroni method was used for correcting for multiple comparisons. Positive estimates indicate higher intra-network functional connectivity in the presence of that maternal covariate, and negative estimates indicate lower intra-network functional connectivity in the presence of that maternal covariate.