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. 2022 Mar 14;13:863039. doi: 10.3389/fimmu.2022.863039

Figure 4.

Figure 4

Waning of humoral protection against Wuhan strain and variants of concern. (A) Reciprocal titers of neutralizing antibodies against Wuhan strain, Alpha (B.1.1.7), Beta (B.1.351), Gamma (B.1.1.28.1), Delta (B.1.617.2) and Omicron (B.1.1.529) SARS-CoV-2-S variants over time, measured using the sVNT. Each individually colored dot and connecting line represent one patient (n=39 patients). Crimson shaded area represents time during the disease. (B) Reciprocal dilution titers of antibodies against Wuhan strain, Alpha, Beta, Gamma, Delta and Omicron variants. Each dot represents one biologically individual sample taken from one patient. N (disease)=23; n (early conv.)=32; n (late conv.)=25. (C) Longitudinal analysis of neutralizing antibodies titers in patients 3-7 months after the disease. Each connected dot represent one individual patient (n=11). (B, C) for better visualization of identical titer values, data were randomly and proportionally adjusted closely around the precise titer results. Statistics: (B) Kruskal-Wallis multiple comparison test with Dunn’s post hoc correction. (C) Two-tailed Wilcoxon matched-pairs signed rank test. *p<0.05; **p<0.01; ***p<0.001.