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D-glucono-1,5-lactone reduced reperfusion-induced arrhythmias. (A) Representative examples of different ventricular arrhythmias (PVC and VT) during 30 min post-reperfusion. Arrhythmia incidence (B), number of PVC (C), number of VT + VF (D), QT duration (E) and corrected QT (F) in I/R-injured mice in the presence or absence of GDL treatment (n = 6). Heart rate (G) of all sections, including baseline, ischemia and reperfusion (n = 6). *P < 0.05 between indicated groups.
