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. 2022 Mar 14;13:856699. doi: 10.3389/fphys.2022.856699

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Copyright © 2022 Qin, Liu, Gao, Hu, Chen, Xu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular signal-regulated kinase signaling contributed to GDL-conferred cardioprotection against H/R injury. (A) The effect of MEK/ERK inhibitor U0126 (10 μM) or PI3K/Akt inhibitor Wortmannin (Wm; 100 nM) on GDL-induced cardioprotection against H/R injury. (B) Time-dependent effect of GDL (0, 2, 4, 8, 12, and 24 h) on ERK expression and phosphorylation by Western blot analysis. (C) Dose-dependent effect of GDL (0 μM, 1 μM, 10 μM, 100 μM, 1 mM and 10 mM) on ERK expression and phosphorylation by Western blot analysis. (D–G) Representative images and Western blot analysis of apoptosis-related proteins (Bcl2, Bax, and Caspase3) and pro-survival ERK signaling in H/R, H/R + GDL, H/R + GDL + U0126, H/R + U0126 groups. *P < 0.05 and **P < 0.01 between indicated groups. NS, not significant. Data shown are representive of five independent experiments.