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. 2022 Mar 14;9:827474. doi: 10.3389/fmed.2022.827474

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Copyright © 2022 Yu, Ma, Liu, Yang, Lin, Yu, Jia, Niu, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Children #22 strain (E. coli) showed FOS- and AK-co-heteroresistance. (A) K-B tests: the heteroresistance phenotypes of the strain to the two drugs. (B) The PAP curve of amikacin. (C) The PAP curve of fosfomycin. Each value was the average of the results of three repeated experiments. The highest drug concentrations on the plates (FOS and AK) were 4 times the MIC for each drug, and the heteroresistant frequencies of both drugs were >1 × 10⁻⁷. Red arrows indicated heteroresistant colonies.