FIGURE 1.

Radiation induces intestinal inflammation and slow blood flow in mice. (A) Survival rate of mice administered with radiation and those that were not. The implemented procedures were as follows: a single irradiation of the lower abdomen of mice with a 6-MV electronic wire; the irradiation range was from the xiphoid to pubic symphysis; the distance from the skin was 10 cm; the dose rate was 260–300 MU/min; the total amount of irradiation was 14 Gy; and the survival rate of mice was calculated during the disease process (n = 10 per group). Mice were exposed to 14-Gy radiation and were returned to the animal room for normal feeding during the next days. All mice were sacrificed at different time points (days 0, 2, 4, and 6). (B) Sections of colonic tissues were separated and stained with hematoxylin and eosin staining to observe the structure of the intestinal wall (n = 4 per group). The photos were observed with a confocal laser scanning microscope at ×50 and ×200 magnifications. (C,D) Intestinal blood flow was detected by laser Doppler and was then calculated (n = 5 per group). *p < 0.05 and **p < 0.01 vs. control group.