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. 2022 Mar 14;13:743708. doi: 10.3389/fphar.2022.743708

FIGURE 2.

FIGURE 2

Paeoniflorin reduces mortality and improves radiation enteritis in mice exposed to radiation. Saline, dexamethasone, and different doses of paeoniflorin (PF) (30, 60, and 90 mg/kg) were injected intraperitoneally into the mice of the respective groups 2 h after they were exposed to 14-Gy radiation on the 1st day. Saline, dexamethasone, and PF were then administered every 24 h from the 2nd to the 14th day. (A) The survival rate of mice was calculated during the disease process (n = 10 per group). (B) The body weight changes during the disease process (n = 6 per group). (C) Sections of colonic tissues were separated and stained with hematoxylin and eosin staining (n = 4 per group). The photos were observed with a confocal laser scanning microscope at ×50 and ×200 magnifications. (D,E) The intestinal blood flow was detected by laser Doppler and was then calculated (n = 5 per group). **p < 0.01 and ***p < 0.001 vs. control group; # p < 0.05 and ### p < 0.001 vs. 14-Gy radiation + saline group; &&& p < 0.001 vs. 14-Gy radiation + saline group.