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. 2022 Mar 14;13:845209. doi: 10.3389/fimmu.2022.845209

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Copyright © 2022 Li, Li, Hu, Wu, Yang, Fan, Li, Luo, Ye, Gao, Xu, Hai and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impaired mitochondrial respiratory chain complexes in the salivary glands from pSS. (A) A heatmap shows significant down regulation in the bulk respiratory chain complex (I–V) genes in pSS from the validation cohort, particularly those encoded in the mitochondria in pSS-high-infiltration group. (B) Heatmap of the Spearman correlation values between respiratory chain complex (I–V) genes and immune responses in pSS from the validation cohort. (C) Immunohistochemical staining for cytochrome c of paraffin-embedded labial salivary gland specimens from our own cohort. Scale bar = 100 μm. (D) Heatmap of the Spearman correlation values between respiratory chain complex (I–V) genes and 4 hub genes (CD38, CMPK2, TBC1D9, and PYCR1) in pSS from the validation cohort. (E–H) Scatter plot depicted the correlation between interested respiratory chain complex genes (MT-CYB, MT-ATP6, COX7A1, NUBPL, COX4I1, CYCS) and CD38 (E), CMPK2 (F), TBC1D9 (G), and PYCR1 (H) based on the data from Figure 6D , respectively.