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. 2022 Mar 14;13:845209. doi: 10.3389/fimmu.2022.845209

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Copyright © 2022 Li, Li, Hu, Wu, Yang, Fan, Li, Luo, Ye, Gao, Xu, Hai and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between 4 hub genes and mitochondrial metabolism, damage-associated molecular patterns (DAMPs). Color represents Pearson’s correlation coefficient r of each hub genes (CD38, CMPK2, TBC1D9, and PYCR1) versus mitochondrial metabolism-related genes and DAMP gene expression, with blue color indicating a positive correlation (Pearson’s r < 0), red color indicating a negative correlation (Pearson’s r > 0). Statistical analysis was done with the Mantel test, with yellow line indicating p value <0.01, green line indicating 0.01 < p < 0.05.