Table 2.
Hub genes in the PPI network (TOP10).
| UniProt ID | Gene name | Protein name | Degree | Closeness centrality | Betweenness centrality |
|---|---|---|---|---|---|
| P04637 | TP53 | Cellular tumor antigen p53 | 49 | 0.82432432 | 0.05833188 |
| P15692 | VEGFA | Vascular endothelial growth factor A | 47 | 0.80263158 | 0.04592475 |
| P05412 | JUN | Transcription factor AP-1 | 47 | 0.80263158 | 0.05446106 |
| P01375 | TNF | Tumor necrosis factor | 47 | 0.80263158 | 0.04090074 |
| P05231 | IL6 | Interleukin-6 | 46 | 0.79220779 | 0.03284284 |
| P00533 | EGFR | Epidermal growth factor receptor | 41 | 0.74390244 | 0.06279942 |
| P01584 | IL1B | Interleukin-1 beta | 41 | 0.74390244 | 0.01996984 |
| P01133 | EGF | Pro-epidermal growth factor | 40 | 0.73493976 | 0.02295494 |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | 40 | 0.73493976 | 0.01653377 |
| P04040 | CAT | Catalase | 39 | 0.73493976 | 0.07478328 |