Table 4.
Association between HOTAIR cluster variants and clinical-demographic characteristics of T2DM patients and healthy controls.
| Variable | Genotype | FBS (mg/dL) | TC (mg/dL) | TG (mg/dL) | HDL-C (mg/dL) | LDL-C (mg/dL) |
|---|---|---|---|---|---|---|
| rs920778 C/T | ||||||
| T2DM | TT TC + CC p value |
186.48 ± 77.38 181.64 ± 69.23 0.763 |
184.50 ± 42.95 184.99 ± 48.26 0.877 |
180.11 ± 98.78 158.83 ± 81.97 0.108 |
52.21 ± 21.41 56.92 ± 18.69 0.016 |
102.33 ± 36.88 95.31 ± 31.35 0.161 |
| Control | TT TC + CC p value |
98.90 ± 15.03 96.75 ± 19.58 0.139 |
181.12 ± 33.09 181.47 ± 37.71 0.655 |
135.57 ± 56.56 130.94 ± 73.78 0.305 |
48.89 ± 16.54 47.11 ± 17.68 0.886 |
100.89 ± 25.71 105.17 ± 28.96 0.589 |
| rs1899663 G/T | ||||||
| T2DM | TT TG + GG p value |
170.05 ± 65.81 183.40 ± 70.79 0.195 |
178.95 ± 35.79 185.42 ± 48.31 0.617 |
163.41 ± 85.91 161.90 ± 84.94 0.940 |
59.82 ± 19.66 55.93 ± 19.12 0.207 |
91.38 ± 20.68 96.79 ± 33.09 0.585 |
| Control | TT TG + GG p value |
94.17 ± 14.73 97.32 ± 19.79 0.058 |
175.03 ± 35.81 182.39 ± 37.49 0.127 |
132.45 ± 60.43 131.17 ± 74.12 0.514 |
50.27 ± 14.58 46.89 ± 17.88 0.243 |
101.44 ± 30.40 105.37 ± 28.48 0.520 |
| rs12826786 C/T | ||||||
| T2DM | TT CT + CC p value |
184.87 ± 72.68 181.82 ± 70.02 0.773 |
181.48 ± 44.71 185.67 ± 48.06 0.585 |
149.92 ± 66.73 164.66 ± 88.25 0.451 |
60.05 ± 22.87 55.37 ± 18.17 0.120 |
94.45 ± 32.38 96.79 ± 32.31 0.730 |
| Control | TT CT + CC p value |
95.45 ± 12.71 97.14 ± 20.00 0.780 |
179.62 ± 30.70 181.70 ± 38.18 0.662 |
129.49 ± 58.42 131.60 ± 74.35 0.971 |
57.10 ± 13.50 46.16 ± 17.61 <0.001 |
96.33 ± 30.68 106.11 ± 28.25 0.065 |
| rs4759314 A/G | ||||||
| T2DM | GG AA + AG p value |
200.27 ± 71.73 197.32 ± 69.85 0.008 |
183.20 ± 46.42 185.21 ± 47.68 0.806 |
174.70 ± 98.02 159.86 ± 82.43 0.403 |
53.92 ± 17.85 56.61 ± 19.38 0.466 |
89.72 ± 27.70 97.52 ± 32.92 0.043 |
| Control | GG AA + AG p value |
95.63 ± 13.44 97.04 ± 19.69 0.602 |
168.88 ± 32.27 182.57 ± 37.57 0.041 |
106.27 ± 55.35 133.62 ± 73.43 0.004 |
48.61 ± 17.59 47.13 ± 17.59 0.481 |
102.36 ± 21.25 105.11 ± 29.37 0.573 |
FBS: fast blood sugar; TC: total cholesterol; TG: triglyceride; HDL-C: high density lipoprotein-cholesterol; LDL-C: low density lipoprotein-cholesterol; T2DM: type 2 diabetes mellitus. p values were adjusted for sex, age, and BMI. p < 0.05 was considered statistically significant (italicized p value).