Figure 2.

Clinical course and imaging findings in the patient with CR-Kp infection. Part-1 Management of the patient prior to his transferring to our department. A: Major therapeutic procedures during the patient's hospital stay. Red dots and blue cross indicated the patient's heart rate and temperature, respectively. Joint antibiotics use was at the bottom of the panel. B: CT scan 2-week after admission showing pulmonary infection and hepatic abscess. C: CT scan 12-day after the patient was transferred in showing right segmental atelectasis and significantly reduced hepatic abscess. D and E: CT scans immediately after the onset of cerebral hemorrhage and 2-week prior to his discharge, respectively. F: CT scan 10-day shortly before the discharge. Part-2 Management of the patient after his transferring to our department. A (continued): Major therapeutic procedures and joint antibiotics use at the bottom of the panel. G: accessory genes by which the four distinct Kp strains were genetically defined (adapted from Ref. 5 by Martin RM et al., Front Cell Infect Microbiol. 2018) H: comparison of the β-lactamase inhibitors and spectrum of inhibition. (adapted from Ref. 25 by Bush K et al., Nat Rev Microbiol. 2019) mNGS: metagenomics next generation sequencing. CRRT: continuous renal replacement therapy. XR-AB and XR-PA: multiple drug resistance Acinetobacter baumannii and Pseudomonas aeruginosa, respectively. HD: hemodialysis. TEC: teicoplanin. IPM: imipenem. FLICZ: fluconazol. DBO: diazabicyclooctanone analogue. ESBL: extended-spectrum β-lactamase. MBL: metallo-β-lactamase.