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. 2022 Mar 14;13:849267. doi: 10.3389/fgene.2022.849267

TABLE 2.

Patients with/without CHD/stroke/PAD and effect of treatment on lipid levels.

Parametr Group Baseline Follow-up N Diference (%) p
N Mean ± SD p N Mean ± SD p
LDL-C (mmol/L) CHD+ 110 6.90 ± 2.21 p = 0.015 113 2.82 ± 1.57 p = 0.002 105 −59.75 p < 0.001
CHD- 1,071 6.43 ± 1.88 973 3.30 ± 1.57 944 −48.53
stroke+ 31 6.84 ± 1.65 p = 0.282 30 2.57 ± 1.20 p = 0.016 30 −62.29 p = 0.007
stroke- 1,150 6.47 ± 1.93 1,056 3.27 ± 1.58 1,019 −49.33
PAD+ 31 7.14 ± 1.86 p = 0.051 32 2.99 ± 1.61 p = 0.342 31 −57.61 p = 0.017
PAD- 1,150 6.46 ± 1.92 1,054 3.26 ± 1.58 1,018 −49.46
TC (mmol/L) CHD+ 119 9.31 ± 2.29 p = 0.020 116 4.88 ± 1.73 p < 0.001 116 −47.57 p < 0.001
CHD- 1,108 8.87 ± 1.92 1,002 5.50 ± 1.67 1,002 −38.27
stroke+ 31 9.46 ± 1.78 p = 0.115 31 4.60 ± 1.33 p = 0.005 31 −51.40 p < 0.001
stroke- 1,196 8.90 ± 1.97 1,087 5.46 ± 1.69 1,087 −38.91
PAD+ 32 9.54 ± 1.97 p = 0.069 32 4.94 ± 1.75 p = 0.096 32 −48.16 p = 0.006
PAD- 1,195 8.90 ± 1.96 1,086 5.45 ± 1.68 1,086 −39.00
ApoB (g/L) CHD+ 57 1.88 ± 0.66 p = 0.135 34 0.98 ± 0.44 p = 0.149 15 −43.20 p = 0.741
CHD- 545 1.77 ± 0.53 328 1.11 ± 0.50 169 −37.46
stroke+ 16 1.78 ± 0.40 p = 0.968 11 0.79 ± 0.36 p = 0.039 4 −68.20 p = 0.033
stroke- 586 1.78 ± 0.54 351 1.10 ± 0.50 180 −37.17
PAD+ 17 2.01 ± 0.57 p = 0.081 9 1.10 ± 0.37 p = 0.954 4 −51.01 p = 0.242
PAD- 585 1.77 ± 0.54 353 1.09 ± 0.50 180 −37.57
TG (mmol/L) CHD+ 118 2.12 ± 1.47 p < 0.001 116 1.42 ± 0.78 p = 0.623 115 −33.55 p = 0.002
CHD- 1,099 1.75 ± 1.05 1,001 1.38 ± 0.78 993 −22.10
stroke+ 30 2.02 ± 0.85 p = 0.235 31 1.29 ± 0.46 p = 0.523 30 −35.74 p = 0.119
stroke- 1,187 1.78 ± 1.11 1,086 1.39 ± 0.79 1,078 −23.13
PAD+ 31 2.06 ± 0.83 p = 0.155 32 1.46 ± 0.67 p = 0.562 31 −28.87 p = 0.365
PAD- 1,186 1.78 ± 1.11 1,085 1.38 ± 0.78 1,077 −23.33
HDL-C (mmol/L) CHD+ 118 1.54 ± 0.43 p = 0.002 116 1.42 ± 0.45 p < 0.001 115 −7.87 p = 0.825
CHD- 1,092 1.68 ± 0.46 991 1.57 ± 0.46 977 −6.68
stroke+ 30 1.58 ± 0.44 p = 0.304 30 1.48 ± 0.52 p = 0.355 29 −7.39 p = 0.947
stroke- 1,180 1.67 ± 0.46 1,077 1.56 ± 0.46 1,063 −6.78
PAD+ 31 1.57 ± 0.41 p = 0.236 32 1.29 ± 0.34 p = 0.001 31 −17.22 p = 0.023
PAD- 1,179 1.67 ± 0.46 1,075 1.56 ± 0.46 1,061 −6.51
Lp(a) (g/L) CHD+ 80 0.72 ± 0.81 p < 0.001 25 0.96 ± 1.24 p = 0.007 25 0.71 p = 0.801
CHD- 872 0.44 ± 0.58 264 0.54 ± 0.66 259 5.31
stroke+ 17 0.53 ± 0.84 p = 0.634 6 0.46 ± 0.36 p = 0.677 6 −53.56 p < 0.001
stroke- 935 0.46 ± 0.60 283 0.58 ± 0.74 278 6.85
PAD+ 23 0.66 ± 0.65 p = 0.112 9 0.43 ± 0.44 p = 0.521 9 2.96 p = 0.916
PAD- 929 0.46 ± 0.61 280 0.59 ± 0.74 275 4.67

N—number of patients; SD, standard deviation; p—p-value.