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. 2022 Mar 9;13:856386. doi: 10.3389/fphar.2022.856386

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Copyright © 2022 He, Ma, Zuo, Zhang, Wang, Zhang, Zhai and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CANA improves the cardiac function by activation of fatty acid oxidation and ketogenesis and reducing oxidative stress through the AMPK/SIRT1/PGC-1a pathway. (A) The protein expression of AMPK, p-AMPK, SIRT1, and PGC-1a was detected via Western blotting; (B) Quantitative evaluation of the protein expression of AMPK and p-AMPK; (C) Quantitative evaluation of the protein expression of SIRT1; (D) Quantitative evaluation of the protein expression of PGC-1a; (E) The mRNA expression of SIRT1 was detected in indicated groups; (F) The mRNA expression of PGC-1a was detected in indicated groups. ^* p < 0.05 vs. NSD. ^# p < 0.05, ^## p < 0.01 vs. HSD.