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CANA improved cardiac function by activation of fatty acid oxidation and ketogenesis and reducing oxidative stress through the AMPK/SIRT1/PGC-1a pathway. (A) The protein expression of AMPK, p-AMPK, SIRT1, and PGC-1a was detected via immunohistochemical staining; (B) Mean density of p-AMPK (IOD/Area); (C) Mean density of SIRT1 (IOD/Area); (D) Mean density of PGC-1a (IOD/Area); IOD, integrated optical density. ** p < 0.01 vs. NSD. ## p < 0.01 vs. HSD.
