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Spatial models of the dyad. (A) Illustration of model structure (left) and different approaches to RyR arrangement (right), ranging from regular lattice through irregular lattice to free-placement. (B) Illustration of a triggered Ca2+ spark occurring in two different RyR arrangements, corresponding to control and right-ventricular heart failure (RV-HF) directly reconstructed from imaging data. Scale bar corresponds to 50 nm. Reproduced with data from Sheard et al. (2019).
