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. 2022 Mar 14;10:819262. doi: 10.3389/fcell.2022.819262

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Copyright © 2022 Zhang, Huang, Xu, Wang, Yao, Xu, Qiao, Gao, Shen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PLK1 expression is decreased in NPCs in IVDD. (A) Preoperative MRI scan of the spine of IVDD. (i) refers to normal intervertebral disc tissue, and (ii, iii) refers to degenerated intervertebral disc tissue. (B) The expression of collagen in NPCs from normal and degenerate IVDs. (C) The mRNA expression of PLK1 in NPCs isolated from different degenerated IVDs. (D) The protein expression of collagen, aggrecan, ADAMTS5, PLK1, and MMP13 in NPCs isolated from different degenerated IVDs. (E) QPCR analyses were performed for collagen, aggrecan, and ADAMTS5. Data are shown as the mean ± SD, *p < 0.05, **p < 0.01, **p < 0.001, ****p < 0.0001. SD, standard deviation.