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. 2022 Mar 14;10:819262. doi: 10.3389/fcell.2022.819262

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Copyright © 2022 Zhang, Huang, Xu, Wang, Yao, Xu, Qiao, Gao, Shen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PLK1 kinase activity aggravates IVDD in a rat model. (A) MRI scans of rat tails. (B) The mRNA expression of collagen, aggrecan, ADAMTS5, and MMP3 was detected in rat tails treated with volasertib or Pifithrin-α. (C) The protein expression of PLK1 pT210, collagen, aggrecan, ADAMTS5 and p21 was detected in rat tail tissues. (D) Immunohistological staining of aggrecan, MMP3, and SOX9 in intervertebral disc from the different groups. (E) Toluidine blue, Alcian blue, safranin O, and H&E staining of intervertebral disc from the different groups. All experiments were performed in duplicates, and data are reported as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. SD, standard deviation.