Table 4.

Mean BDNF concentrations during Trier social stress test (TSST).

BDNF	Pre-TSST	Post-TSST	Post-90-TSST
HC (N = 21)	23,053.15 ± 4,818.28	14,993.06 ± 3,882.56*	11,782.55 ± 4,138.4*
MDD (N = 6)	22,510.41 ± 5619.91	15,912.88 ± 3,456.21	14,872.87 ± 2,471.91
CUD-induced-MDD (N = 9)	28,040.91 ± 5,287.74	18,854.29 ± 4,662.07*	17,144.84 ± 6,581.06*
CUD-primary-MDD (N = 16)	27,076.84 ± 8,457.33	18,735.27 ± 6,045*	12,627.27 ± 5,488.09*
CUD (N = 15)	22,739.07 ± 5,673.17	16,423.37 ± 4,950.92*	15,888.35 ± 5,050.1*
One-way ANOVA	p = 0.082	p = 0.125	p = 0.032

^*Paired T-Test < 0.05.

HC, healthy controls; MDD, major depression disorder; CUD, cocaine use disorder; TSST, Trier social stress test.