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. 2022 Mar 29;79(4):215. doi: 10.1007/s00018-022-04235-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Modular structures of the ART enzymes PARP1, PARP2, PARP3, tankyrase 1, tankyrase 2 and the shelterin proteins TRF1 and TRF2. The amino acid numbers indicate domain boundaries. The known interactions between the ART enzymes and shelterin proteins and the domains involved are indicated by purple (PARP1/TRF2), pink (PARP2/TRF2) and light blue (Tankyrases1/2/TRF1) shadings. The PARylated domains of TRF1 and TRF2 are also indicated (see text for more details)