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. 2022 Mar 29;13:1667. doi: 10.1038/s41467-022-29292-7

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A On the side bar panel each objective is represented with a slider. Users can decide which objectives to include in the optimization and can also specify direction of optimization (minimize or maximize). B Additional tools to explore the results. Relative view shows profiles of recommended genes. Bar plots demonstrate standardized values across objectives and top recommended genes. Co-occurrence heatmap demonstrates clusters of genes frequently mentioned together in EGFR TKI resistance context.