Skip to main content
. 2022 Mar 29;12:129. doi: 10.1038/s41398-022-01881-6

Fig. 1. Comparative lipid profile of EC and PVC of aged APOE targeted replacement mice.

Fig. 1

a Heatmap of lipids significantly altered by APOE3/4, APOE4/4 and APOE3/3 genotype in EC and PVC at 14–15 months of age. Each row represents a lipid species of a given category (see color legends); each column represents a sample. Results are expressed as Z-score [(average mol% of lipid species per genotype−average mol% of lipid species in all genotypes)/standard deviation of average mol% lipid species] represented in gradient color; blue and red indicate negative and positive Z-score, respectively. One-way ANOVA was performed and results thresholded by p < 0.05; n = 8, 6, and 8 for EC and n = 7, 8, and 7 for PVC in APOE3/3, APOE3/4, and APOE4/4 mice, respectively. b, c Volcano plots of differentially modulated lipid species in EC and PVC between APOE3/4 vs. APOE3/3, APOE4/4 vs. APOE3/3 and APOE4/4 vs. APOE3/4. Colored plots denote significantly affected species at Tukey’s post-hoc p < 0.05, black plots denote unaltered species (p > 0.05).