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. 2022 Mar 29;12:129. doi: 10.1038/s41398-022-01881-6

Fig. 2. Dominant and semi-dominant effects of APOE4 expression on lipid composition in the EC in aged APOE mice.

Fig. 2

a–c Normalized average mol% (fold-change) of (a) DAG, (b) BMP, (c) Hex and (d) Cer lipid species from the EC of aged APOE targeted replacement mice. Lipids were annotated per total acyl carbons and degree of unsaturation. Data represent median ± max/min. One-way ANOVA followed by Tukey’s post-hoc test for multiple comparisons was performed; n = 8, 6, and 8 for EC and n = 7, 8, and 7 for PVC in APOE3/3, APOE3/4, and APOE4/4 mice, respectively. Kruskal–Wallis H test confirmed statistically significant difference in levels of BPM 32:0 (p = 0.03), HexCer 16:0 (p = 0.003) and Hex Cer 16:1 (p = 0.003). *p < 0.05, **p < 0.01, and ***p < 0.001.