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. 2022 Feb 1;14:377–388. doi: 10.1016/j.bioactmat.2022.01.041

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Effects of hypoxic pretreatment on protein expression of SHEDs and the characterization of exosomal cargo. (A) Significantly upregulated and downregulated proteins (Hypo-SHEDs vs. Nor-SHEDs). (B) GO enrichment of up-regulated proteins in Hypo-SHEDs compared with Nor-SHEDs. (C) Technical illustration of the production of Exo and H-Exo. (D) Exosome protein concentration, (E) TEM images (scale bar: 100 nm), and (F) NTA analysis of Exo and H-Exo. (G) Western blot analysis of the expression of surface protein markers including TSG101, HSP70 and CD9. (H) Clustered heatmap of differentially expressed genes depicting the up and downregulated circRNAs and (I) corresponding KEGG enrichment of up-regulated circRNAs.