Table 2.

Differentially expressed genes, gene modules, and estimated^a immune cell types between treatment arms at year 2

	Lower expression in the abatacept arm		Lower expression in the adalimumab arm
	ID	Function	ID	Function
Genes	IGHA1 IGHA2 IGKC	Antibody production	CXCL1 IL1b	Cytokine signaling
	CTLA4 SLAMF1 TIGIT	Cell co-stimulatory signaling	MMP9	Collagen degradation
	HLA-DPB1	Antigen presentation	LCN2 CAMP CEACAM3 ADM	Innate immune response
	CCR4 CCR5 CXCR6	Chemokine receptors	ORM1	Acute phase inflammation
Immune gene modules	M3.6	IL-2-activated NK cells	M6.16	Cell cycle, metaphase
	M4.10	B Cells	M9.42
Estimateda immune cell types	Plasma cells B cells NK cells		Granulocytes

^aFrom cell-specific gene signatures generated using isolated immune cells

IL interleukin, NK natural killer

Reprinted from ACR Convergence held November 3–8, 2017. The American College of Rheumatology does not guarantee, warrant, or endorse any commercial products or services. Reprinted by Bristol Myers Squibb