Fig. 1.

Schematic demonstrating the fabrication of MSCs-laden injectable self-healing hydrogel for systemic sclerosis (SSc) treatment after subcutaneous injection in SSc mice. (A) Schematic diagram of self-healing process of hydrogel. (B) Reaction scheme to show crossing-linking of PEG-BA and CS-CM via the Schiff-base reaction and the application in bleomycin induced SSc disease model mice. (C) Schematic diagram for investigation of the paracrine products generated by MSCs under the influence of hydrogel to modulate the cell communication network toward anti-fibrosis.