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. 2022 Jan 19;17:369–378. doi: 10.1016/j.bioactmat.2022.01.006

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 5 — MSCs promoted HUVECs angiogenesis and migration in vitro. (A) Representative images of wound healing assay in medium (NC group) and conditional medium (MSCs group). (B) Wound healing assay results are quantified in the histogram. (C) Fluorescent images of HUVECs cultured in cell culture flask (Control group), cell culture flask covered by matrigel (NC group) and cell culture flask covered by matrigel in MSCs conditional medium (MSCs group). The scale bar is 200 μm. (D) Statistical analysis of total tube number and length in each group. *P < 0.05, **P < 0.01. KEGG analysis of top 5 enriched up-regulated (E) and down-regulated (F) terms in MSCs group compared with NC group. (G) The expression of markers genes in MSCs and NC groups.