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. 2022 Feb 1;14:364–376. doi: 10.1016/j.bioactmat.2022.01.042

Fig. 7.

Fig. 7

In vivo bone regeneration under osteoporotic conditions after implantation for 4 weeks: (a) Reconstructed transverse, coronal, and 3D micro-CT images; (b–e) Quantitative analysis of the micro-CT data including (b) BMD, (c) BV/TV, (d) Tb.N and (e) Tb.Sp (n = 5 per group); (f) Red fluorescent labeling of new bone formation surrounding the implants; (g) Histological observation of the peri-implant tissues after H&E staining with new bones marked by dashed lines; (h) Histological observation of the peri-implant tissues after toluidine blue staining; (i) Histological observation of the peri-implant tissues after TRAP staining. OB, old bone; NB, new bone; Yellow arrows mark the fibrous capsule; Red arrows mark the direct contact between new bone and the implants; Black arrows mark the TRAP positive cells. *p < 0.05 compared to PEEK, #p < 0.05 compared to PEEK-ALN.