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. 2022 Jan 21;17:379–393. doi: 10.1016/j.bioactmat.2022.01.007

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Ex vivo evaluation of bone healing effect of the nwHA bioceramics implanted in an osteoporotic rat model with bone defect. (A) Gross observation and micro-CT reconstructed images of the nwHA bioceramics implanted in rat metaphyseal bone with osteoporosis. (B) First line: 2D cross-sectional X-ray images of the implant-bone interface; Second line: 3D micro-CT rendered images of the trabecular bone adjacent to the defect as the VOI; Third line: FEA predicted total deformation of the VOI under load. (C) Quantification of gap bone fraction (gBV/TV), ingrown bone volume fraction (iBV/TV), adjacent bone volume fraction (aBV/TV), and maximum von Mises stress of VOI. All data are reported as mean ± standard error. ANOVA with Tukey's post hoc test *p < 0.05, **p < 0.01, ***p < 0.001.