Table 2.

Recent patents and patent applications in the field of injectable, osteoinductive CPCs.

Title	Benefit	Status	Ref
Preparation method of injectable calcium phosphate cement modified with PEG cladding photosensitizer IR780, product and application	Good injectability	Appl.	[152]
Preparation method of polyanhydride modified controllable biodegradable calcium phosphate bone cement as well as product and application thereof	Controllable biodegradability	Appl.	[151]
Preparation method of lanthanide-doped injectable calcium phosphate bone cement as well as product and application of bone cement	Good injectability, possibility to use as a bone cement with fluorescent label	Appl.	[153]
Preparation method of rapid degradation controlled drug release injectable bone cement and product and application of rapid degradation controlled drug release injectable bone cement	Good injectability and prevented brittleness	Appl.	[154]
Chitosan quaternary ammonium salt-modified antibacterial calcium phosphate bone cement and preparation method and use thereof	Good injectability, suitable curing time and excellent antibacterial performance	Appl.	[155]
Preparation method of injectable bone cement modified by medicine carrying organic zirconium phosphate, and product and application thereof	Improved injectability and the collapse resistance of the bone cement, slow release of drugs	Appl.	[156]
Preparation method of nano-zinc oxide modified antibacterial injectable calcium phosphate bone cement as well as products and application thereof	Good injection properties, proper curing time, and excellent antibacterial properties	Patent	[157]
Rapidly-degradable injectable type bone cement and application thereof	Porous structure, promoted bone cement degradation and the ingrowth of bone cells, shortened setting time, improved compressive strength, promoted cell proliferation	Appl.	[158]
Injectable porous calcium phosphate cement and preparation method thereof	Good injectability, presence of macropores and micropores, appropriate setting time, good biocompatibility, simple preparation method, easy operation	Appl.	[160]
Injectable bone cement capable of promoting growth and preparation method of injectable bone cement	Enhanced mechanical performance, good antibacterial performance, promoted regeneration of bone cell tissues	Appl.	[159]
Method of making injectable cements	Excellent osteoconductivity and osseointegration, strong bonding to drug molecules	Patent	[179]
Resorbable radioopaque cross-calcium phosphate cement for bone plastics	Simplified composition of the radiopaque injected calcium-phosphate cement, optimal flow and radiopacity parameters without the introduction of special improvement additives, increased safety of use	Patent	[184]
Solidifying liquid capable of regulating injectability of calcium phosphate bone cement and preparation method and application of solidifying liquid	Simple, rapid and efficient preparation method, the prepared bone cement has strong cohesive force before solidification, the liquid and solid are not separated in the injection process, and the injectability and compressive strength are both good	Patent	[162]
Porous brushite-based injectable bone filler for application in vertebroplasty and preparation method of the bone filler	Injectability sufficiently high enough that cement slurry can be injected through a needle having a diameter of 10–15 gauge, a high level of reabsorption	Patent	[177]
Injectable continuous antibacterial anti-inflammation bone cement and preparation method thereof	Slow release effect on anti-inflammatory drugs, continuous long-acting antibacterial and anti-inflammation action	Patent	[178]
Injection type degradable high-mineralization-activity composite bone cement and preparation method thereof	Improved collapse resistance, excellent compressive strength and injectability	Appl.	[173]
Brushite bone cement as well as preparation method and application thereof	Excellent mechanical properties, controllable curing time (can be adjusted to be between 10 min and 1 min), good injectability	Appl.	[163]
Bone cement with hyaluronic acid	Significant improvement of the physical and mechanical parameters of cement compositions, as well as other clinically relevant properties	Appl.	[164]
Injectable and moldable osteoinductive ceramic materials	Favorable osteoinductive properties	Patent	[165]
Flowable bioactive bone void filler	Osteostimulative, bioactive and flowable for injection through a syringe	Appl.	[171]
Self-setting calcium phosphate cement with independently adjustable initial setting time and final setting time	Wider adjustable ranges of the initial setting time and the final setting time, wider adjustable range of pH	Appl.	[166]
Injectable bone cement composition kit containing calcium phosphate with fiber and preparing method of the same	Compromise between curing time, injecting power, and large porosity	Patent	[172]
Porous injectable calcium phosphate bone cement compound	Internal pore size 10 μm–50 μm, porosity of about 60%, favorable pore connectivity, accelerated degradation of bone cement, biocompatibility and bone repair capacity, good fluidity	Appl.	[175]
Bone cement with induction and degradation characteristics and preparation method of bone cement with induction and degradation characteristics	Excellent compressive strength, biocompatibility, bone conductivity and bone inductivity, and degradation speed of the bone cement is equivalent to bone growth speed. The bone cement can be made into different dosage forms by control of a liquid-solid ratio	Appl.	[167]
Preparation method of high-strength injectable polyphase calcium phosphate-based bone cement	Excellent injectability, collapse resistance, after 7 days of solidification at 37 °C, the mechanical compression strength reaches 113.68+/7.11Mpa	Appl.	[168]
Injectable calcium phosphate ceramic for promoting tendon bone healing and preparation method and application thereof	Promoted tendon bone healing, early fixation	Appl.	[180]
Novel injection self-condensing composite artificial bone carrying rhBMP_2 micro spheres	Good bone forming osteoinductive performance, and high mechanical strength, good degradation rate	Appl.	[176]
Strontium ion-mediated self-curing calcium phosphate bone cement	Enhanced degradation, applicable as a drug carrier	Appl.	[169]
Developable and injectable calcium phosphate bone cement, and its preparation and application	Compressive strength ≥9 MPa, injectable time ≤8 min	Appl.	[174]
Osteoinductive bone material	Compressive strength greater than at least 1 MPa	Patent	[182]
Methods and compositions for the treatment of degenerate bone	Injectable biomaterial	Appl.	[181]
Method for producing an osteoinductive calcium phosphate and products thus obtained	Porous, osteoinductive implant material	Patent	[185]
Macroporous and highly resorbable apatitic calcium-phosphate cement	Injectable CPC, that may comprise antibiotics, anti-inflammatory drugs, anti-cancer drugs, drugs against osteoporosis, and growth factors	Patent	[170]
Osteoinductive calcium phosphates	Porous, osteoinductive implant material having interconnected porosity	Patent	[183]