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. 2022 Mar 15;13:842340. doi: 10.3389/fimmu.2022.842340

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Copyright © 2022 Vadakumchery, Faraidun, Ayoubi, Outaleb, Schmid, Abdelrasoul, Amendt, Khadour, Setz, Göhring, Lodd, Hitzing, Alkhatib, Bilal, Benckendorff, Al Shugri, Brakebusch, Engels, Datta, Hobeika, Alsadeq and Jumaa

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Rapid elimination of CLL B cells after inducible deletion of RhoA. (A) Representative picture of spleen size of diseased mice treated with or without Tamoxifen. (B) Flow cytometric analysis showing elimination of CLL B cells (CD19⁺CD5^low) after 3 weeks of tamoxifen induction. (C) Absolute number of splenic CLL B cells. N=3 mice per group, unpaired t-test, two-tailed. (D) Kaplan-Meier survival curve showing the survival of Eµ-TCL1 RhoA^fl/fl Mb1^+/CreERT2 mice after Tamoxifen-induced RhoA deletion (+Tam) or without treatment (-Tam). Results from 3 individual mice are indicated (n=3). The P-value was determined by Mantel-Cox log-rank test (*p < 0.05, ****p<0.0001).