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The role of CXCL8 signaling in tumor biology. CXCL8 recruited MDSCs, TAMs, and TANs to the TME. CXCL8 could be secreted by tumor cells, CAFs, MDSCs, and TAMs. CXCL8 could promote tumor cells proliferation and EMT, directly and indirectly. CXCL8 could facilitate the accumulation of pro-tumorigenic immune cells and tumor immune suppression, and inhibit anti-tumor immune cells in direct and indirect ways.
