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. 2022 Mar 15;13:784463. doi: 10.3389/fimmu.2022.784463

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Copyright © 2022 Maruyama, Fuzo, Oliveira, Rogerio, Takamiya, Pessenda, de Melo, da Silva, Jesus, Carregaro, Nakaya, Almeida and da Silva

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular deconvolution of blood transcriptomes in human visceral leishmaniasis using the CIBERSORT method: (A) Leukocyte proportions inferred from gene expression profiles of blood samples. Plots by cell type displaying the relative cell proportions for eosinophils (B), neutrophils (C), plasma cells (D), activated memory CD4 cells (E), CD8 T cells (F), monocytes (G), activated NK (H) cells and resting NK cells (I). Groups were classified as active VL (PD0) and VL-free (PD180, A and C groups), in which the PD180 subjects were treated and considered clinically cured after 180 days of disease follow-up (PD0 and PD180 are paired groups, n = 11); A: asymptomatic (n = 9); C: healthy uninfected controls (n = 9). The differences between cell proportions were evaluated by Wilcoxon with Holm’s correction. *P < 0.05, **P < 0.01, and ***P < 0.001.