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. 2022 Mar 15;13:859206. doi: 10.3389/fmicb.2022.859206

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Copyright © 2022 Sun, Zheng, Chen, Lu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Natural polysaccharides improve high-fat diet (HFD)-induced metabolic diseases through regulating gut microbiota. Plants or animals-derived polysaccharides are fermented by gut microorganism, and produce metabolites, such as short-chain fatty acids (SCFAs). In turn, these metabolites regulate the intestinal microbiota composition. HFD induce gut microbiota dysbiosis that contributes to obesity-associated chronic metabolic diseases. In this regard, natural polysaccharides reverse HFD-induced metabolic diseases by regulating gut microbiota.