FIGURE 1.

Diurnal variation in QT interval and cardiac events in LQTS patients. (A) Schematic cartoon diagram of the diurnal variation of corrected (white) and uncorrected (grey) QT intervals (Bonnemeier et al., 2003; Smetana et al., 2003) over a long day photoperiod diurnal cycle. (B) Schematic summary of the times of day when patients with different subtypes of LQTS most frequently experience cardiac events (Matsuo et al., 1999; Takigawa et al., 2012; Aizawa et al., 2016; Pérez-Riera et al., 2018). Yellow background indicates daytime and grey background indicates night-time. Dotted line indicates the transition between morning, afternoon and evening phases of the diurnal cycle.