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. 2022 Feb 21;13(5):1398–1409. doi: 10.7150/jca.58053

Figure 5.

Figure 5

Enhanced NUS1 expression promotes malignant phenotype of ccRCC cells. (A) The RT-qPCR showed that NUS1 was up-regulated in four ccRCC cell lines (A-498, CAKI-1, CAKI-2, and 786-O) compared with normal kidney cells (HK-2). (B-C) The mRNA and protein expression level of NUS1 in control group, transfecting siNUS1-1 group, transfecting siNUS1-2 group, and transfecting pcDNA3.1-NUS1 group. (D-E) The proliferation ability of A-498 and 786-O cells in control group, transfecting siNUS1-1 group, and NUS1 overexpression group. (F-G) Representative images of invasion of A-498 and 786-O cells between control group, siNUS1-1 group, and NUS1 overexpression group. (H) Quantification analysis of results from (F) and (G). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.