Figure 1.

CircASPM is up-regulated in glioblastomas tissues and correlated with the progression and poor prognosis. a: Loop formation procedure of circASPM was illustrated. b, c: CircASPM expression was significantly higher in glioma tissues than in normal brain tissues based on GEO datasets GSE109569. d: CircASPM expression was correlated with WHO grades in glioma. e, f: Kaplan-Meier analysis of all patients or GBM patients in terms of higher circASPM expression versus low circASPM expression. g: Sanger sequencing validated the specific junction of circASPM. h, i: qPCR analysis of ASPM mRNA and circASPM in GSC11 and GSC18 treated with Rnase R. j: half-life detection confirmed the circular characteristics of circASPM. All data are shown as the mean ± SD (three independent experiments). *P < 0.05; **P < 0.01; ***P < 0.001.