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. 2022 Mar 14;13(5):1664–1678. doi: 10.7150/jca.57691

Figure 7.

Figure 7

CircAPSM mediated GBM cells proliferation via E2F1expression. a, b: H&E-stained brain sections of mice with circAPSM knockdown in GSC18 were transplanted intracranially. The brain was harvested on the 15th day after transplantation. CircAPSM knockdown significantly inhibits tumor growth in vivo. Scale bar = 1 mm. c, f: The copy number of circASPM in tumor tissues derived from mice. d, e: H&E-stained brain sections of mice with circAPSM overexpression in GSC11 were transplanted intracranially. The brain was harvested on the 15th day after transplantation. CircAPSM overexpression significantly enhances tumor growth in vivo. Scale bar = 1 mm. g: Kaplan-Meier survival curve of circAPSM knockdown in GSC18 mice. h: Kaplan-Meier survival curve of circAPSM overexpression in GSC11. i: Representative immunohistochemical staining showed the changes in H&E, E2F1, and ki-67 staining in circAPSM overexpression and knockdown orthotopic xenograft models. Scale bar=50 μm. All data are shown as the mean ± SD (three independent experiments). *P < 0.05; **P < 0.01; ***P < 0.001.