Table 1.

Studies on growth hormone therapy in short-stature patients with Kyphoscoliosis.

Reference	Year	Findings
Polgreen & Miller (2)	2010	Short stature due to progressive growth failure is common in all MPS diseases.
Hardin (3)	2008	GH is an effective treatment for growth failure associated with GHD, Turner syndrome, chronic renal diseases, and several other conditions.
Souza & Collett-Solberg (8)	2011	Side effects of rhGH replacement therapy in children and adolescents prepubertal gynecomastia, arthralgia, edema, benign intracranial hypertension, insulin resistance, progression of scoliosis, and slipped capital femoral epiphysis.
Rabbani et al. (15)	2013	The common causes of short stature identified were familial short stature, hypothyroidism, growth hormone deficiency, insulin dependent diabetes mellitus, and constitutional delayed growth and maturation.
Day et al. (16)	2007	In this study, there was no evidence of HGH treatment being responsible for the progression of scoliosis in a small number of non-syndromic patients.
Jawa et al. (58)	2016	Growth hormone and Vitamin-D deficiency constitute one of the major causes of short stature among well-nourished children with short stature in Pakistan.
Moayeri & Aghighi (60)	2004	Most children with short stature will not have an endocrine disorder (60).
Vidil et al. (61)	2001	It is difficult to conclude that GH is the only factor responsible for the worsening of the scoliosis.
Yun et al. (62)	2017	Radiographic examination revealed that growth hormone therapy cCobb angle and apical vertebral translation on the coronal plane.
Shiva & Nikzad (63)	2009	GHD is not a common cause of short stature.
Guyda (64)	1994	GH will dramatically increase final height in short children.