Table 4.

All systemic symptoms (n  = 321; 100.0%) reported in 79 patients. Data are presented as n (%).

Symptoms	Patients
Neurological
Central and peripheral	62 (19.3)
Cognitive/memory/concentration	16 (20.3)
Paresthesiaanesthesia	13 (16.5)
(Poly)neuropathy	8 (10.1)
Proprioception loss/difficulty walking	7 (8.9)
Headache	4 (5.1)
Hyposthenia/asthenia	3 (3.8)
Spasm/musclecramps	3 (3.8)
Lower motor neuron syndromes	2 (2.5)
Axonopathy	1 (1.3)
Bulbarpalsy	1 (1.3)
Convulsions	1 (1.3)
Neuropaticpain	1 (1.3)
Parkinson	1 (1.3)
Tremors	1 (1.3)
Sensory*	77 (24.0)
Hearing impairment/loss	34 (43.0)
Visual impairment/retinaldysfunction	25 (31.6)
Dysgeusia/metallic taste	9 (11.4)
Tinnitus	5 (6.3)
Vertigo	2 (2.5)
Loss of smell/anosmia	1 (1.3)
Opticnervearthrophy	1 (1.3)
Cardiovascular	71 (22.1)
Dyspnoe/apnoe/orthopnea	25 (31.6)
(Peri)cardiomyopathie	12 (15.2)
Heart failure	10 (12.7)
Tachycardia	5 (6.3)
Cardiogenic shock	4 (5.1)
Exertionalchest tightness/pain	4 (5.1)
Oedema	4 (5.1)
Pericarditis	2 (2.5)
Hypertension	2 (2.5)
Syncope	2 (2.5)
Pericardial effusion	1 (1.3)
Gastroenterology	12 (3.7)
Diarrhea	3 (3.8)
Nausea	3 (3.8)
Vomiting	3 (3.8)
Anorexia	2 (2.5)
Liver failure	1 (1.3)
Musculoskeletal	5 (1.6)
Arthromyalgia	1 (1.3)
Decreasedmusclemass	1 (1.3)
Polyarthralgia	1 (1.3)
Polymyalgia	1 (1.3)
General stiffness	1 (1.3)
Skin/hair	8 (2.5)
Rash/dermatitis/sarcoid-like	6 (7.6)
Diaphoresis	1 (1.3)
Hair loss	1 (1.3)
Thyroid	9 (2.8)
Hypothyroidism/thyroiddysfunction	9 (11.4)
Mental/pschosocial	25 (7.8)
Fatigue	17 (21.5)
Depression	4 (5.1)
Anxious	2 (2.5)
Insomnia	2 (2.5)
Other	20 (6.2)
Weight loss	7 (8.9)
Weakness	4 (5.1)
Fever	2 (2.5)
Malaise	2 (2.5)
Polydipsia	2 (2.5)
Multi-organ failure	1 (1.3)
Polycythemia	1 (1.3)
Uncontrolled diabetes	1 (1.3)

^*Visual, auditory, gustatory olfactory, somatosensory and vestibular.