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. 2022 Mar 15;12:856712. doi: 10.3389/fonc.2022.856712

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Copyright © 2022 Li, Liu, Dong, He, Liu, Wei, Mou, Zhang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of CHPF is significantly higher in breast cancer and negatively correlated with overall survival. (A) ATCGA data analysis shows high expression of CHPF gene in breast cancer tissues. (B) Expression levels of CHPF genes in paired breast samples. (C) The results of KM survival analysis based on TCGA-BRCA data (p = 0.002, log-rank test). (D) The results of KM survival analysis based on breast cancer GEO dataset GSE20685 (P = 0.001, log-rank test). (E) Univariate COX regression analysis shows CHPF gene expression as a poor prognostic factor. (F) CHPF protein expression was detected by western blotting in fourteen paired LUAD tissue. (G) Western blotting detected the protein levels of CHPF in six breast cell lines.