TABLE 3.

Linear mixed model analyses examining the rate of change in CKD‐MBD variables over the first 365 days after a diagnosis of azotemic CKD in cats (n = 51)

Variables	Group	Time	Group × Time
Body weight (kg)	.22	<.01	.30
Albumin (g/dL)	.29	.59	.29
ALP (U/L)	.73	.40	.71
ALT (U/L)	.57	.85	.34
CaPP (mg2/dL2)	.19	.02	.39
Chloride (mEq/L)	.38	.78	.44
Creatinine (mg/dL)	.35	<.01	.04
PCV (%)	.25	<.01	.48
Phosphate (mg/dL)	.10	.02	.45
Potassium (mEq/L)	.67	.85	.50
Sodium (mEq/L)	.13	.37	.16
Total calcium (mg/dL)	.34	.98	.95
Total protein (g/dL)	.98	.08	.73
Urea (mg/dL)	.55	<.01	.21

Note: Summary of P‐values for all variables included in the model. Group represents cats in “grade 0,” “grade 1,” or “grade 2” based on the severity of nephrocalcinosis. Outcome variables showing significant change over time and among groups (P < .05) are highlighted in bold. The unit used for time was month (30.4 days). A significant difference in the group column indicates a significant difference among the 3 groups at baseline for a given parameter (the start of the regression line at time 0). A significant difference in Group × Time indicates that the outcome variable differs significantly among groups (“grade 0” vs “grade 1” vs “grade 2”) over time. If Group × Time was not significant, a significant difference in Time indicates the overall rate of change of the outcome variable differs significantly from baseline over time. See Table S1 for a summary of intercepts and the slopes of time within each group.

Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; CaPP, calcium phosphate product.