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. 2022 Mar 15;13:821026. doi: 10.3389/fgene.2022.821026

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Copyright © 2022 Lusk, Hoffman, Mahaffey, Rosean, Smith, Silhavy, Pravenec, Tabakoff and Saba.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative trait loci (QTL) for voluntary alcohol consumption in the HXB/BXH recombinant inbred panel. Strain means were used in a marker regression to determine phenotypic QTL. The blue line represents the logarithm of the odds (LOD) score threshold for a suggestive QTL (genome-wide p-value = 0.63). Suggestive QTL are labeled with their location, 95% Bayesian credible interval, LOD score, and genome-wide p-value. Empirical genome-wide phenotypic QTL p-values were calculated using 1,000 permutations.