TABLE 3.
Transcripts in the brain candidate coexpression module for predisposition to voluntary alcohol consumption. Transcripts are ordered by intra-modular connectivity, and the source that identified the transcript is shown. The total number of transcripts with the same gene ID as the individual candidate transcript (i.e., isoforms of the same gene) in the detected above background transcriptome, and the source(s) identifying the transcripts, is also shown. Strain mean normalized expression estimates and strain mean voluntary alcohol consumption values were used to determine Spearman’s rank correlation coefficients.
| Transcript ID | Gene symbol | Gene description | Source | Chromosome: Start position-end position (Mb) (strand) | Intra-modular connectivity | Transcript correlation with alcohol consumption (correlation coefficient (p-value)] | Number of transcripts identified in HXB/BXH RI panel | Number of ensembl/StringTie/aptardi transcripts |
|---|---|---|---|---|---|---|---|---|
| ENSRNOT00000066952.1 | Ift81 | Intraflagellar transport 81 | aptardi | 12:39.42–39.51 (+) | 1.22 | −0.44 (0.0487) | 3 | 0/1/2 |
| MSTRG.6250.1 | Lrap | Locus regulating alcohol preference | StringTie | 12:39.01–39.02 (−) | 1.14 | −0.45 (0.0417) | 1 | 0/1/0 |
| MSTRG.6281.1 | Mapkapk5 | MAPK activated protein kinase 5 | StringTie | 12:40.51–40.53 (+) | 1.10 | −0.49 (0.0238) | 3 | 2/1/0 |
| MSTRG.19929.1 | AABR07065438.1 | Ribosomal protein L6, pseudo 1 | StringTie | 6:128.74–128.74 (+) | 1.01 | 0.51 (0.0191) | 1 | 0/1/0 |
| ENSRNOT00000090867 | Oas3 | 2′-5′-oligoadenylate synthetase 3 | Ensembl | 12:41.32–41.34 (+) | 1.01 | 0.60 (0.0043) | 1 | 1/0/0 |
| ENSRNOT00000001752 | P2rx4 | Purinergic receptor P2X 4 | Ensembl | 12:39.31–39.33 (−) | 1.00 | −0.58 (0.0059) | 2 | 1/1/0 |