Table 4.

Unadjusted and multivariate Cox regression analyses for all-cause mortality.

	Unadjusted HR (95% CI)	P-value	Adjusted HR (95% CI)	P-value
Total
GNRI
Low nutritional risk (≥93.1)	Ref	_	Ref	_
nutritional risk (<93.1)	2.85 (2.00–4.08)	<0.001	2.01 (1.37–2.96) a	<0.001
PNI
Low nutritional risk (≥43.6)	Ref	_	Ref	_
High nutritional risk (<43.6)	3.11 (2.02–4.77)	<0.001	2.04 (1.29–3.23) b	0.002
CONUT
Low nutritional risk (≤4.5)	Ref	_	Ref	_
High nutritional risk (>4.5)	2.12 (1.51–2.98)	<0.001	1.54 (1.07–2.23)b	0.021
Severe DFUs
GNRI
Low nutritional risk (≥93.1)	Ref	_	Ref	_
nutritional risk (<93.1)	1.96 (1.24–3.07)	0.004	2.07 (1.28–3.35)c	0.003
PNI
Low nutritional risk (≥43.6)	Ref	_	Ref	_
High nutritional risk (<43.6)	1.92 (1.14–3.22)	0.014	1.51 (0.87–2.60)d	0.141
CONUT
Low nutritional risk (≤4.5)	Ref	_	Ref	_
High nutritional risk (>4.5)	1.43 (0.94–2.17)	0.095	1.28 (0.82–2.00)d	0.285
No severe DFUs
GNRI
Low nutritional risk (≥93.1)	Ref	_	Ref	_
nutritional risk (<93.1)	3.94 (2.18–7.11)	<0.001	2.19 (1.14–4.22)c	0.019
PNI
Low nutritional risk (≥43.6)	Ref	_	Ref	_
High nutritional risk (<43.6)	5.37 (2.50–11.53)	<0.001	3.71 (1.59–8.63)d	0.002
CONUT
Low nutritional risk (≤4.5)	Ref	_	Ref	_
High nutritional risk (>4.5)	3.36 (1.87–6.03)	<0.001	2.39 (1.28–4.48)d	0.006

^aThe multivariable Cox regression was adjusted for risk factors including age, SBP, severe DFUs, lymphocyte, Hb, eGFR.

^bThe multivariable Cox regression was adjusted for risk factors including age, SBP, severe DFUs, BMI, Hb, eGFR.

^cThe multivariable Cox regression was adjusted for risk factors including age, SBP, lymphocyte, Hb, eGFR.

^dThe multivariable Cox regression was adjusted for risk factors including age, SBP, BMI, Hb, eGFR. GNRI, geriatric nutritional risk index; PNI, prognostic nutritional index; CONUT, controlling nutritional status. Ref, reference; DFUs, diabetic foot ulcers; SBP, systolic blood pressure; eGFR, estimated glomerular filtration rate; Hb, hemoglobin.