Table 3. Concentrations of Chemokines and Cytokines in the Aqueous Humor of AMD Patients and Healthy Controls.
| AMD (n=12) | Control (n=6) | p value | Test | ||
|---|---|---|---|---|---|
| Chemokine, pg/mL | |||||
| IL-8 | 15.3 (9.7–29.5) | 12.8 (6.9–14.2) | 0.180 | Mann-Whitney U test | |
| IP10 | 15.0 (11.9–76.2) | 12.6 (9.2–15.3) | 0.102 | Mann-Whitney U test | |
| CCL11 | 19.7 (16.9–22.4) | 23.2 (14.7–26.6) | 0.553 | Mann-Whitney U test | |
| TARC | 35.3 (29.7–47.6) | 41.4 (23.7–50.6) | >0.999 | Mann-Whitney U test | |
| MCP-1 | 765.3 (509.5–1199.3) | 454.5 (413.9–574.2) | 0.018 | Mann-Whitney U test | |
| RANTES | ND | ND | >0.999 | Mann-Whitney U test | |
| MIP-1α | 13.9 (10.5–14.6) | 13.8 (9.5–17.8) | 0.820 | Mann-Whitney U test | |
| MIG | 0.0 (0.0–1.2) | 0.0 (0.0–0.2) | 0.130 | T-test | |
| ENA-78 | 8.2 (7.3–9.4) | 9.0 (6.1–9.8) | 0.892 | Mann-Whitney U test | |
| MIP-3α | 23.7 (22.4–30.4) | 28.2 (15.3–35.5) | 0.750 | Mann-Whitney U test | |
| GROα | 60.4 (57.2–72.8) | 78.7 (47.9–94.0) | 0.494 | Mann-Whitney U test | |
| I-TAC | 6.7 (6.2–7.6) | 9.2 (4.1–10.1) | 0.494 | Mann-Whitney U test | |
| MIP-1β | 11.3 (10.0–12.8) | 9.8 (7.1–12.0) | 0.180 | Mann-Whitney U test | |
| Cytokine, pg/mL | |||||
| IL-5 | 6.8 (5.9–7.4) | 8.4 (6.0–9.2) | 0.125 | Mann-Whitney U test | |
| IL-13 | 16.1 (12.5–19.7) | 22.4 (14.2–33.9) | 0.180 | Mann-Whitney U test | |
| IL-2 | 18.2 (13.5–20.0) | 27.6 (10.5–36.5) | 0.250 | Mann-Whitney U test | |
| IL-6 | 12.3 (8.0–17.5) | 25.0 (8.0–30.8) | 0.437 | Mann-Whitney U test | |
| IL-9 | 4.9 (4.3–5.2) | 6.2 (4.9–6.8) | 0.053 | Mann-Whitney U test | |
| IL-10 | 4.2 (3.8–4.8) | 6.8 (4.3–9.1) | 0.053 | Mann-Whitney U test | |
| IFN-γ | 42.2 (23.9–52.1) | 56.0 (37.4–97.0) | 0.125 | Mann-Whitney U test | |
| TNF-α | 5.3 (4.7–9.5) | 15.6 (4.5–19.1) | 0.067 | Mann-Whitney U test | |
| IL-17a | 3.8 (3.5–4.1) | 4.2 (3.5–4.7) | 0.437 | Mann-Whitney U test | |
| IL-17f | 5.2 (4.0–5.6) | 4.8 (3.2–6.4) | 0.964 | Mann-Whitney U test | |
| IL-4 | 0.0 (0.0–0.0) | 15.4 (4.4–31.8) | 0.018 | Mann-Whitney U test | |
| IL-21 | 3.1 (2.8–3.7) | 3.3 (2.9–3.6) | 0.820 | Mann-Whitney U test | |
| IL-22 | 44.7 (9.4–74.4) | 102.3 (48.6–116.8) | 0.041 | Mann-Whitney U test | |
ND, not determined; IP10, interferon gamma-induced protein 10; CCL, C-C motif chemokine ligand; TARC, thymus and activation regulated chemokine; MCP, monocyte chemoattractant protein; RANTES, regulated on activation, normal T cell expressed and secreted; MIP-1α, macrophage inflammatory protein 1-alpha; MIG, monokine induced by gamma interferon; ENA-78, epithelial-derived neutrophil-activating peptide 78; GRO, growth-regulated oncogene; I-TAC, interferon-inducible T-cell alpha chemoattractant; AMD, age-related macular degeneration; IL, interleukin; IFN, interferon; TNF, tumor necrosis factor.
Data are presented as median (±interquartile range).