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. 2022 Mar 30;78:103972. doi: 10.1016/j.ebiom.2022.103972

Figure 1.

Fig 1

Longitudinal dynamics of neutralizing and anti-N antibody responses to SARS-CoV-2 infection from outpatient and hospitalized individuals. a,b. The half-maximum inhibitory concentration (IC50) of sera was determined by microneutralization assay of recombinant vesicular stomatitis virus carrying SARS-CoV-2 spike protein (rVSV-SARS2-S). a. Neutralizing antibody (nAb) titres (log10 IC50) from n = 30 outpatients (116 samples; grey circles) and n = 35 hospitalized (112 samples; red circles) at 2 to 37 days post-symptom onset. c. Longitudinal nAb titres (log10 IC50) from n = 36 outpatients (85 samples) and n = 31 hospitalized (58 samples) taken from day 23 (outpatients) or day 25 (hospitalized) until day 414 post-symptom onset. c,d. The end-point titres of anti-N IgG were determined by ELISA using a recombinant SARS-CoV-2 nucleocapsid protein. Samples and time points are the same as those in A and B. a-c. The second order polynomial (quadratic) curve fitting was used to establish the days at which peak titres occurred (Ymax). b–d. Continuous decay fit is shown with the red and gray line for the corresponding patient group. Every data point represents results from two technical replicates.