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The biosafety assay of POS-UCNPs/ICG. (A) Dark toxicity and phototoxicity (1 W·cm-2, 5 min) of POS-UCNPs/ICG at different concentrations. (B) Control, 1 h, 4 h and 24 h animal imaging of POS-UCNPs/ICG metabolism in vivo (Control group was injected with PBS). (C) Control, 1 h, 4 h and 24 h organs imaging of POS-UCNPs/ICG metabolism in vivo (Control group was injected with PBS). (D) Histological images of H&E staining of major organs in BALBC/c mice 60 days after injection.
