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CDs-based cancer therapy via drug delivery. (A) Design and mechanism of MitoCAT-g to amplify oxidative stress in mitochondria and cause apoptotic cell death. (B) Schematic illustration of the synthesis process of CAT-g. (C) Schematic illustration of the establishment of the orthotopic PDX tumour model in NOD-SCID mice. (D) Scheme of the treatment schedule. (E) Effect of the different formulations on animal body weight. Adapted with permission from 221, copyright 2019 Springer Nature.
