Figure 13.
CDs-based cancer therapy by PTT. (A) Synthetic route of PPA. (B) Synthetic route of CDs. (C) The absorption of water-dispersible CDs. (D) Temperature elevation of pure water and the aqueous dispersion of CDs with different concentrations under laser irradiation. (E) Plot of temperature change over a period of 600 s versus the aqueous dispersion of CDs with different concentrations. Adapted with permission from 116, copyright 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (F) Schematic illustration of the generation of proteasome inhibitor-encapsulated CuS/carbon dots nanocomposites (CuSCDB@MMT7). (G) Schematic illustration of the application of CuSCDB@MMT7 for enhanced PTT via heat-stabilization of various substrates in the ubiquitin-dependent proteasomal degradation pathway. Adapted with permission from 129, copyright 2020, American Chemical Society.